Osteoblast differentiation from synovial fluid cells in juvenile idiopathic arthritis (JIA)
نویسندگان
چکیده
Purpose Juvenile idiopathic arthritis (JIA) is one of the leading causes of disability in children characterized by destruction of articular cartilage and underlying bone, as well as synovial hyperplasia. Since synovia contains osteoblast progenitors, hyperplastic changes may contribute to joint destruction by inhibition of osteoblast differentiation. Osteoblasts are also immunoregulatory cells and their inhibited differentiation and function may affect joint inflammation. The objective of this report is to explore the osteoblastogenic potential of synovial fluid cells in JIA and to examine whether synovial fluid from children with JIA effects osteoblast differentiation of human bone marrow cells in vitro. Additionaly, we aimed to determine and compare the local and systemic expression of osteoblast related genes in patients with JIA.
منابع مشابه
Osteoblastogenesis from synovial fluid-derived cells is related to the type and severity of juvenile idiopathic arthritis
INTRODUCTION Juvenile idiopathic arthritis (JIA) is characterized by synovial inflammation, followed by hyperplastic changes of the synovium, and destruction of articular cartilage along with underlying bone. This hyperplastic process is the result of inflammation-induced activation of NF-κB, which may be accompanied by decreased osteogenic differentiation of synovial mesenchymal progenitors an...
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